There's an interesting 'sample' protocoal for "orthomolecular medicine (OM) ideas that can help alleviate depression, fatigue, muscle pain, and joint pain, as well as other symptoms that may appear in chronic fatigue.

The author included herbs as part of OM protocol - which isn't true, but this article gives a good idea of what an OM practitioner would suggest. Don't forget though - OM is based on individual biochemistry! What works for your neighbour, might not work exactly for you...

(first paragraph of article) 

I've recently read that Niacin (B3) helps to regulate or enhance your metabolism. Can anyone recommend a good dosage to start, assuming I'm healthy otherwise?I'd love to have a little more pep in my step without resorting to even more caffeine or whatever else is out there!Or any other vitamin supplements someone can recommend? I wouldn't say I'm chronically fatigued, per se, but who couldn't use some extra energy/vitality/whatever-you-wanna-call-it?Any and all help is appreciated!

The "Chronic Fatigue Syndrome" is a multifactorial collection of illnesses which are very hard to distinguish from each other, but with fatigue, myalgia, cognitive impairments, and often digestive disturbances in common. The diagnosis is by exclusion of other conditions. This leaves the management. There is , as yet, no single cure. But a staged approach frequently leads to major improvement, if not cure.

According to a national governmental survey in 1981, fatigue was the single most common presenting complaint in medical practice. Specifically, approximately 15 million persons sought medical assistance with a primary complaint of tiredness. Causes of disease are often problems of metabolism which are expressed in different ways such as tiredness, exhaustion, fatigue. When the organism is in optimal condition, there is well-running digestion, excretion, respiration, locomotion, reproduction.

A 46-year-old white male came to The Center with a three year history of severe fatigue, “body achiness”, sweating spells, progressive memory loss or “forgetfulness” and depression. His regular physician had diagnosed chronic fatigue syndrome secondary to Epstein-Barr virus infection, hypertension and chronic sleep apnea (he was overweight). The patient stated that his career and family life has suffered greatly as a result of his conditions.

The patient is a 55 year old female, married with three adult children and is employed as an elementary school teacher. She had been seen previously by numerous physicians for treatment of long standing "depression". Just prior to her first visit to The Center she was under the care of a psychologist and a psychiatrist.

Chronic Fatigue Syndrome (CPS) is an ilinesa with a primary complaint of persistent or relapsing fatigue along with multiple, non-spedfic symptoms. These symptoms can include headaches, recurrent sore throats, muscle and joint pains and cognitive conplaints. The fatigue can come on suddenly or gradually, but must last for at least six months and is not alleviated by rest. The fatigue results in substantial reduction in previous levels of work, school or persona! activities. In 1994 the diagnostic criteria of CFS was established by an international panel for the U.S.

The "Chronic Fatigue Syndrome" is a multifactorial collection of illnesses which are very hard to distinguish from each other, but with fatigue, myalgia, cognitive impairments, and often digestive disturbances in common. The diagnosis is by exclusion of other conditions. This leaves the management. There is , as yet, no single cure. But a staged approach frequently leads to major improvement, if not cure.

Chronic Fatigue Syndrome (CFS) is a vexatious, damaging and, all too often, lethal condition. It causes immense losses to society because those who suffer from it are almost always those who would be making the maximum contribution were they well.

http://orthomolecular.org/library/jom/1999/articles/1999-v14n02-p116.shtml